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Mitre, who is of Mexican American descent, graduated from Montgomery High School in San Diego, California, June 1999. He and his wife, Tonya, have a son named Sam (Sergio Armando Mitre III), who was born on December 29, 2006.
Mitre was the Chicago Cubs 7th-round selection in the 2001 Major League Baseball Draft out of San Diego City College. He was the second player out of the 2001 draft to make it to the majors with the Cubs, the first being Mark Prior. Mitre made his major league debut for the Cubs in 2003 after being called up from the West Tenn Diamond Jaxx (at the time, West Tenn was the Cubs' Double-A affiliate). He played in 3 games in 2003 (2 starts) and had an 0-1 record with an 8.31 ERA.
In 2004, Mitre started out the season on the Opening Day roster, filling in for the injured Mark Prior. He was sent down to the Triple-A Iowa Cubs after Prior came back from injury. On August 13, 2004, Mitre pitched a complete game shutout against the Albuquerque Isotopes. Mitre gave up only a double and a walk, both coming in the first inning of the game. After this, Mitre sat down 23 straight batters, striking out 9 batters in the game. He became the Pacific Coast League‘s Player of the Week.  He finished the Iowa Cubs 2004 season (after going back and forth to Chicago) with a 6-4 record, and a 2.97 ERA.
In 2005, Mitre started off on Triple-A Iowa's roster, and on May 10, 2005, he was recalled from Iowa, only to be sent down after two games and not pitching in either. On May 24, 2005, he was called up for a spot start. On June 14, 2005, Mitre pitched his first complete game, along with his first shutout in a 14-0 victory over the Florida Marlins against Josh Beckett.
In the 2007 season, Mitre won a career-high five games. He also set career bests with 27 games played, 27 starts, 149.0 innings pitched and 80 strikeouts. Mitre had a streak of not allowing an earned run in 24.2 consecutive innings. This streak lasted five starts, beginning May 20 at Tampa and ending June 15 at Kansas City. He made Marlins history with his 1.12 ERA in May, only the second lowest for a starting pitcher during May in Marlins history, a feat previously held by Chris Hammond, who turned in a 0.61 ERA in May 1994. Mitre began to see injury problems beginning in 2007, missing two weeks with a blister on his right middle finger, and time later in the season for a strained right hamstring. He had three stints on the disabled list, foreshadowing his 2008 season.
Mitre did not play in a game in 2008. On July 15, Mitre underwent Tommy John ligament replacement surgery to fix right forearm tightness. As is the case with all Tommy John surgery patients, he was expected to miss 12 – 18 months. He was released by the Marlins at the end of the 2008 season.
New York YankeesEdit
Mitre was suspended for the first 50 games of the 2009 season after testing positive for androstenedione in August 2008. Mitre claims that the androstenedione came from a contaminated legal supplement purchased from GNC, but took full responsibility for his actions. He served his suspension while still on the disabled list from last year's Tommy John surgery.
Mitre returned to action, pitching well in nine starts for the Single-A Tampa Yankees and Triple-A Scranton/Wilkes-Barre Yankees. Replacing an injured Chien-Ming Wang, Mitre was called up to the majors to start against the Baltimore Orioles on Tuesday, July 21, 2009. Mitre pitched 5 2/3 innings, allowed 3 runs, and got the win.
- ↑ Rosters. World Baseball Classic. Retrieved on 2010-05-12.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 
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- ↑ Badenhop has MRI on ailing shoulder | floridamarlins.com: News
- ↑ Mitre undergoes season-ending surgery | floridamarlins.com: News
- ↑ Yankees sign Mitre to Minors deal
- ↑ Yankees RHP Mitre to Get 50 Game Suspension ESPN.com, January 6, 2009
- ↑ Diamond, Jared (2009-07-17). Yanks to give Mitre a start against O's | MLB.com: News. MLB.com. Retrieved on 2010-05-12.
- Career statistics and player information from MLB, or ESPN, or Baseball-Reference, or Fangraphs, or The Baseball Cube