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There were two Southern Illinois Leagues. The first operated in 1895as an independent league. In 1896 it was rated as an unclassified league. and the second League was 1910 as a Class D.

1895     Belleville IL, Cairo, IL, Duquion IL, East St Louis IL, Edwardsville IL, Murphysboro IL.

1896     Centralia IL, Duquion IL, Murphysboro IL, St Louis Mo

1910     Eldorado IL, Harrisburg IL, Herrin IL, McLeansboro IL, Mt Vernon IL